factor v leiden mutation造句

• In both methods, the time it takes for blood to clot is decreased in the presence of the factor V Leiden mutation.
• Individuals heterozygous for the Factor V Leiden mutation carry a risk of venous thrombosis 5 7 times higher than in the general population.
• The risk of developing a clot in a blood vessel depends on whether a person inherits one or two copies of the factor V Leiden mutation.
• The previously reported relationship of inflammatory bowel disease ( i . e ., Crohn's disease or ulcerative colitis ) and prothrombin G20210A or factor V Leiden mutation have been contradicted by research.
• The presence of acquired risk factors for venous thrombosis including smoking, use of estrogen-containing ( combined ) forms of hormonal contraception, and recent surgery further increase the chance that an individual with the factor V Leiden mutation will develop DVT.
• The Factor V Leiden mutation at Arg 506 renders Factor Va resistant to inactivation by activated protein C . As a result of this resistance, the half-life of Factor Va in plasma is increased, resulting in increased thrombin production and increased risk of thrombosis.
• Examples of genetic tendencies include protein C deficiency, protein S deficiency, the Factor V Leiden mutation, hereditary anti-thrombin deficiency and prothrombin mutation G20210A . An important non-genetic risk factor is the use of estrogen-containing ( combined ) forms of hormonal contraception.
• Considering that the risk of developing an abnormal blood clot averages about 1 in 1, 000 per year in the general population, the presence of one copy of the factor V Leiden mutation increases that risk to between 4 in 1, 000 to 8 in 1, 000.